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Acne under magnifying Glass of Science

Hi.


Let me start off with Thank You. For finding our page, looking into the BLOG section and taking your time to read our first article. We hope it will be as interesting read for you as hard we tried to make it that way. And now, straight to the topic...


There is 650 million people globally suffering from Acne Vulgaris. That's a lot. In fact, that's twice of an entire US population. That's also almost 10% of Global population. Which means every 10th human being we pass on the streets is affected by this skin disorder. The big question is - WHY?


In this article we will be taking more of a scientific approach for better understanding of the problem. You see - acne is one of the most complicated disorders to fight with. It is caused by bacterias, fungi, sebum, hormones, food....or is it?


It's actually non of those. Bacterias and Fungi - including those directly related with acne - are part of healthy skin ecosystem. Sebum is part of natural excretion function for Sebaceous Glands. And hormones - they are the rainbow of your emotions, thoughts, physiology, habits. Non of it is the predator to your body. But there is this one thing, this genius control panel that defines how all good and bad things are manifested via our skin. It's ours Genetics.




In one of the latest publication from University of California, San Diego, George Y. Liu, MD, Ph.D., professor and chief of the Division of Pediatric Infectious Diseases at UC San Diego School of Medicine and team, had a chance to directly compare "good" (health-associated) and "bad" (acne-associated) strains of P. acnes bacteria in a way that is more relevant to human acne than in previous attempts.


As a result, it was concluded that the genetics of the particular humans and the genetics of the acne-associated strain of P. ances are directly linked with the skin lesions. Interestingly, if all humans were genetically the same, the "bad" acne strains would cause twice as severe skin lesions, that the "good" strains of P.acnes bacteria. There is however one important condition - excess of sebum. It was observed, that regardless of the P.acnes strain, no skin changes can be seen without presence of sebum.


It is now widely accepted that the human microbiota (microorganisms on the skin), the plethora of microorganisms that reside on and in the body, plays an essential role in the maintenance of health and the onset or progression of disease. Skin microbiota provide the first line of protection against environmental factors and pathogens. The microbiota consists of both 'resident' and 'transient' microbes, and is constantly in flux, changing alongside environmental and host factors such as ultraviolet exposure, environmental microbes, personal hygiene and consumer care products, host hormone levels, sebum and sweat.


The follicular unit microbiome (the total genomic component) consists of bacterias, viruses and fungi.

In another research ( The British Journal of Dermatology.  2019;181(4):691-699) we find out the much larger eukaryotic cells (fungi) have the potential to interact with several thousand times the biomass of their prokaryotic (bacteria) counterparts.That potentially means, it is not only bacterias but also fungi that could be responsible for causing acne. This is also the reason, why we decided to include in our acne treatment kit unrefined and extra virgin coconut oil. It has got not only anti-bacterial but also anti-fungal properties.


And finally, we wanted to touch upon the hyperkaratynization, as most suggests the excess of keratin is the only factor promoting this disorder and as a result, contributing to the development of acne. However, P.acnes in its pathological form creates a "biofilm" on the surface of the skin. This biofilm acts as a 'biological glue' bringing keratinocytes together and therefore normal function of these cells to detach or slough off (desquamate) from the skin lining at normal intervals is invalidated.


Analyzing and implementing the above was one of the biggest challenges for us creating the No More Pimple. We concentrated all our efforts to bring back the normal skin homeostasis and therefore prevent the development of new acne lesions and heal the existing ones in the shortest possible time.


We invite all your questions, comments and input related with this article or our product. Thank you for staying with us till the end.





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